Correlation of digoxin-tablet dissolution-rate with biological availability.
نویسندگان
چکیده
منابع مشابه
Therapeutic non-equivalence of digoxin tablets in the United Kingdom: correlation with tablet dissolution rate.
Seven types of digoxin 0.25 mg tablet in common use in the United Kingdom were administered to a total of 38 patients. Significant differences were found in the mean plasma digoxin levels and in the control of atrial fibrillation achieved with these brands. There was a close correlation between the dissolution rate of the tablets and the plasma digoxin levels. Measurement of in-vitro dissolutio...
متن کاملElectric current density imaging of tablet dissolution.
The Electric current density imaging technique (CDI) was used to monitor the dissolution of and ion migration from tablets of different acids in agar-agar gel. Conventional MRI cannot monitor these processes, since it can only show changes in the size of the tablet during the dissolving process. CDI traces the dissolved ions thanks to changes in conductivity.
متن کاملRecent changes in biological availability of digoxin. Effect of an alteration in 'Lanoxin' tablets.
Steady-state digoxin levels were recorded in patients using 'Lanoxin' (Burroughs Wellcome) tablets made before and after the recent change in the manufacture of this brand of digoxin tablet. Levels obtained with the newer Lanoxin tablets were two-thirds higher than those recorded with tablets produced before the change in manufacture. The biological availability of the most commonly used other ...
متن کاملBiological availability of digoxin from Lanoxin produced in the United Kingdom.
Though established quality control standards were maintained, the bioavailability of digoxin from Lanoxin tablets produced in the United Kingdom fell in 1969, and was restored in 1972. After 1.5 mg doses of representative batches, tablets made between 1969 and 1972 produced mean values for area under the 50 hours plasma concentration/time curve of 36.6 ng/ml/hr and four-day urinary excretion of...
متن کاملDigoxin immunoassay with cross-reactivity of digoxin metabolites proportional to their biological activity.
Our objective was to identify commercially available digoxin immunoassays whose cross-reactivity with digoxin metabolites paralleled the pharmacological activity of the metabolites. We measured the immunoreactivity of digoxigenin bis- and monodigitoxosides, digoxigenin, and dihydrodigoxin in four immunoassays and compared the immunoactivities with pharmacological activities from studies involvi...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: British Journal of Clinical Pharmacology
سال: 1977
ISSN: 0306-5251
DOI: 10.1111/j.1365-2125.1977.tb00700.x